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TZD and fenretinide, a synthetic retinoid, both lower circulating RBP4 levels in rodents, and this is associated with improved insulin action in rodent models of obesity and insulin resistance ().

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Insulin sensitivity can be restored to its original state, well, perhaps not to its original state, but you can restore it to the state of about a 10-year-old.

This mechanism is quite fast-acting and may induce insulin resistance within days or even hours in response to a large lipid influx.

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