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Although further research on the value of valproate preparations is indicated, current evidence does not support use of this drug to control agitation of people with dementia.

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Divalproex sodium delayed-release tablets (divalproex sodium) are indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures.

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Since patients were being titrated off another antiepilepsy drug during the first portion of the trial, it is not possible, in many cases, to determine whether the following adverse reactions can be ascribed to divalproex sodium delayed-release tablets alone, or the combination of valproate and other antiepilepsy drugs.

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In one, multiclinic, placebo controlled study employing an add-on design, (adjunctive therapy) 144 patients who continued to suffer eight or more CPS per 8 weeks during an 8 week period of monotherapy with doses of either carbamazepine or phenytoin sufficient to assure plasma concentrations within the "therapeutic range" were randomized to receive, in addition to their original antiepilepsy drug (AED), either divalproex sodium or placebo.

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Among the subjects receiving a mood stabilizer plus an antidepressant, there were no significant differences in the rate of any primary or secondary outcome between subjects receiving bupropion and those receiving paroxetine.

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However, the amount of time participants spent talking in the recreation area during the 390-min recreation period was significantly decreased by active marijuana as compared to baseline (baseline, time talking: 96 16 min; active marijuana, time talking: 28 8 min).

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Divalproex ER is not approved for children under 10 years old and should rarely be used in young children, due to the risk of liver damage.

Results will be discussed by first describing any significant effects of active marijuana as compared to baseline, followed by the effect of withdrawal from marijuana compared to baseline, and finally the effect of active THC compared to placebo during withdrawal from marijuana.

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