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How serious is PBC? The fatigue in PBC is not linked to the severity of the liver disease. Patients can have early disease but still have profound fatigue, while others with more advanced disease may have no fatigue at all. Portal hypertension usually occurs after a patient develops cirrhosis.
How does ursodiol help the liver? Ursodiol is a naturally-occurring bile acid that is made by the liver in humans and is secreted in small quantities into bile. It is used to dissolve and prevent cholesterol gallstones and to treat primary biliary cirrhosis, a disease of the liver. It also reduces the absorption of cholesterol from the intestine.
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