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This brings up the questions of confidence in surrogate endpoints as well as confidence in the finding from a single trial.

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Any modifications took into account the antimicrobial spectrum of the study drugs, since the investigators were unaware of the antibiotics that each patient actually received.

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We note that a recent single technology appraisal with cost analysis, done by an independent evidence review group of NICE concluded that febuxostat should be recommended for ULT in gout only in patients with contra-indications or intolerance to allopurinol ().

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Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: certain antibiotics such as chloramphenicol (chloromycetin), penicillins, and tetracyclines; folic acid (available alone or as an ingredient in some multivitamins); other medications for rheumatoid arthritis; phenytoin (Dilantin); probenecid (Benemid); sulfonamides such as co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), and sulfisoxazole (Gantrisin); and theophylline (Theochron, Theolair).

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Review of efficacy and safety of cidofovir for CMV retinitis in HIV-infected patients; nephrotoxicity is the major dose limiting adverse effect; no mention of hepatotoxicity or ALT elevations during therapy).

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