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I was 37 when my gastroenterologist diagnosed me with duodenal ulcer. It all started as strange burning sensation in my stomach and then developed into almost unbearable pain after every meal. At that time I had constant business trips and couldn't undergo a comprehensive medical check-up. So to avoid the pain I reduced the amount of meals and gradually nearly brought myself to the grave. When I finally found myself to be exhausted, pale and looking as a walking dead, I decided it was high time to dedicate some time to my health and visit a doctor. After the diagnosis was set the doctor prescribed me with a strict diet, medication treatment course and advised me to get closer to healthy lifestyle. I did what I could - ate healthy foods, cooked more, consumed less fast food, stopped drinking wine and beer. However as it seems to me, the most effective thing that helped me gradually heal my duodenal ulcer was medicamental treatment with Carafate. This drug really made the ulcer disappear in less than half a year and according to my doctor this is a very good result at my condition. So I am grateful to Carafate.

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When I was selecting a college to enter the most important factor for me was remoteness from my native town as I desperately wanted independence and freedom, as probably every teenager. I got the freedom but together with it I got a lot of problems to solve. I had to care about my food, clothes and health on my own, without any help from my parents. As I also had lots of friends to spend time with, lots of entertainment ideas, I tried to save time on less important duties. So instead of cooking healthy food for myself I ate fast food mostly. In a year and a half I started having strange feelings in my stomach, the feeling gradually turned into burning pain and soon the pain grew absolutely unbearable, especially after meals. My mother insisted on my visiting a doctor, so in a month I was diagnosed with acute gastric ulcer. I thought it was not a big problem - a week or two on medications and there we go - healthy and renewed again. But the diet I had to observe opened my eyes. Cereals and water, if to sum it up; everything without salt and spice. I had to choose: tasty food and horrible pain afterwards or tasteless food and hope for recovery. Luckily I had enough brain to choose the second. I was also prescribed with Carafate to provide for quicker ulcer healing. It took me lots of efforts patience and more than a year to get rid of the ulcer. Luckily it was not too bad and I managed to recover without surgery. Carafate worked out pure miracles for me! Now I am much cleverer and reasonable.

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CONCLUSION: We show that EGCs conditioned medium, with both pathogen and probiotic bacteria, may differently modulate IECs differentiation without exerting cytotoxic effects, with a mechanism involving RAGE stimulation on IECs.

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