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I have been suffering from chronic angina for about seven years. At the beginning everything was not horrible at all. I just had minor discomfort in my chest after eating and sometimes also used to wake up in the night from pain in my chest. But with the time the symptoms increased in number and their severity. I have been diagnosed with chronic angina in 2007 and since that time I am constantly trying to find a medication that will help me cope with the symptoms and live my life as a normal human being. The problem was not only in the unpleasant sensation that I used to experience but also in the risk of developing a more serious form of the disease that could even require a surgery. Since the time I was put on Ranolazine things has got much easier as the drug is very effective. It helps me control my angina and I no longer feel the pain. According to my doctor, currently there is no risk of serious complications. And all this is due to Ranolazine which turned out to be a real salvation for me. Now I can sleep normally, and all the symptoms I had are easily eliminated with one pill of Ranolazine. Try out the drug if your problem is chronic angina and you haven't found your best medication yet.
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My cardiologist diagnosed me with stable angina about a year ago. At that time I experienced tightness in my chest and pain when breathing after some exercises. That considerable spoiled my life as I enjoy climbing and often stay in the mountains with my friends. He put me on some medication and the on second day of taking it I developed some itching and rash on my arms. However I decided that was from mosquitoes or some strange food and paid no attention and naturally continued on the medication. The rash wouldn't disappear and having come back home I visited a dermatologist. He said it was not a skin disorder and probably some intolerance of a new drug. I went to the cardiologist again and he told me to stop taking the medication and prescribed Ranolazine. With this med I had no itching or rash. The angina also created considerably less problems that before. No I could control the pain and had no more problems with breathing. It's been two months since I have started on Ranolazine and I am absolutely ok with it.

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As previously reported, the MARISA trial ( ) enrolled patients who were 21 years of age or older with coronary artery disease and at least a 3-month history of stable exertional angina.

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However, our findings suggest a benefit of ranolazine as antianginal therapy in a substantially more broad population of patients with established ischemic heart disease than previously studied.

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CABG, which have consistently reported no overall difference in survival between the two interventional techniques, possibly related to the low risk of the populations studied.

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These included both randomized trials and retrospective cohort studies concerning the use of ranolazine in different clinical settings; prevention of atrial fibrillation in patients with acute coronary syndrome, prevention as well as conversion of postoperative atrial fibrillation after coronary artery bypass grafting, conversion of recent-onset atrial fibrillation, sinus rhythm maintenance in drug-resistant recurrent atrial fibrillation and facilitation of electrical cardioversion in cardioversion-resistant patients.

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Study procedures included a clinic visit with physical examination, questionnaires, electrocardiographic examination, 6-minute walk test, exercise echocardiographic examination, and invasive hemodynamic assessment at baseline and at the 3-month visit.

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Overexpression of PPARα in the heart results in a marked increase in cardiac fatty acid uptake, fatty acid β-oxidation, and lipid overload due to an increased expression of the enzymes involved in these processes ().

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QT-prolonging drugs, potassium channel variants resulting in a long QT interval, in patients with a family history of (or congenital) long QT syndrome, or in patients with known acquired QT interval prolongation.

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Damman P, Hirsch A, Windhausen F, Tijssen JG, de Winter RJ.

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The management of CAD patients encompasses lifestyle modification, control of CAD risk factors, evidence-based pharmacological therapy and patient education.

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Moreover, the sample size and duration of therapy in these trials were not designed to evaluate the effect of ranolazine for secondary prevention of major cardiovascular events.

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Detailed whole-cell patch-clamp and extracellular multielectrode recordings revealed significant prolongation of the action-potential duration in LQTS human iPSC-derived cardiomyocytes (the characteristic LQTS phenotype) when compared to healthy control cells.

The diagnosis and immediate management of STEMI and the management of unstable angina and NSTEMI is addressed in other NICE Clinical Guidelines (CG95 and CG94).

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Q-Wave Infarction Strategies in-Hospital) study, and the MATE (Medicine versus Angiography in Thrombolytic Exclusion) trial, did not find routine catheterization to be superior to reserving catheterization for patients with recurrent ischemic symptoms or a significantly positive stress test result.

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