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This phase II also showed that pertuzumab does not work by itself, but needs to be combined with trastuzumab.
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Long-term ill effects of radiotherapy usually are not a notable issue in treatment of brain metastases or in the relatively short survival of these patients.
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There is also a decent amount of preclinical data suggesting that Aromasin has a beneficial effect on bone mineral metabolism that isnot seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are notfound in the non-steroidal Letro and A-dex (9).
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These investigators performed a systematic review of the literature for full text English language articles using MEDLINE, EMBASE, SCOPUS, Cochrane Library databases, NHS Economic Evaluation Database and EconLit.
Patterns of fatigue during the course of cancer treatments vary according to the type of treatment.
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Other therapies, like aromatase inhibitors, lower the level of estrogen in the body so the cancer cells cannot get the estrogen they need to grow.
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Pertuzumab, in combination with trastuzumab with or without chemotherapy, has been evaluated in two preoperative clinical trials in an attempt to improve on the pCR rates observed with trastuzumab and chemotherapy.
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There are three aromatase inhibitors: Arimidex, Aromasin, and Femara (chemical name: letrozole).
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Six Cycles of Doxorubicin and Cyclophosphamide or Paclitaxel Are Not Superior to Four Cycles As Adjuvant Chemotherapy for Breast Cancer in Women With Zero to Three Positive Axillary Nodes: Cancer and Leukemia Group B 40101.
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