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I wanted Prolia but insurance would not cover. I was familiar with zoledronic acid during the phase III studies. I knew about the "flu-like" symptoms. I was NOT prepared for how bad I felt after this infusion. Infusion is painless, easy, and took about 1 hr in total. The headache started within 10 min and lasted 3 days. Fever of 102 with Tylenol. Shaking chills so bad I could not get to the bathroom and ended up peeing on the floor. Blurred vision and my eyes hurt. Not sure if this will be effective until I have another DEXA. Plan for 4 days to recover.
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I dreaded the side-effects and had NONE. I had the intravenous infusion three days before Christmas 2011 and was scared that I would be flattened by the supposed side-effects like flu-like symptoms, bone ache and so forth and was pleasantly surprised. I am having my second one in just ten days time and hopefully it will be a repeat of the first one.
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The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
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Reclast was used two years after the first fracture.
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Schneider, who had gone into menopause prematurely in her early 40s, was riding in a New York City subway when the car jolted.
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After adjustment for the inability to rise from a chair, spending four hours or less on one's feet, and poor health, however, a history of falling and the number of falls were no longer significantly associated with hip fracture.
Right now, the agents that have the best evidence to support using them in previously treated patients are Alimta (pemetrexed), Tarceva (erlotinib), and the standard chemo agent Taxotere (docetaxel).
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Treatment for osteoporosis includes medicine to reduce bone loss and build bone thickness.
Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
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This helps ease symptoms such as pain, bone damage and fracture.
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The good news is that eventually the pain did disappear and I am happy I did not give up because after my treatments, I no longer had any fractures as before, every turn of my body could and often did cause a fracture.
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Data from the study net predefined safety endpoints in the treatment of patients with long-term non-union tibial fractures, allowing the company to expand into the phase II stage of the trial and enroll patients with appendicular, or fresh, non-union fractures.
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Risk factors for developing renal failure include underlying moderate to severe renal impairment, use of kidney-damaging (nephrotoxic) or diuretic medications at the same time as Reclast, or severe dehydration occurring before or after Reclast is given.
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All trials that randomized patients with primary breast cancer to undergo adjuvant treatment with any bisphosphonate versus non-use were considered eligible.
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An affected person is at risk for frequent breaks of the long bones or collapse of the vertebral bones.
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Due to uncertainty surrounding the model assumptions, it would be valuable to repeat the analyses using data from comparative bisphosphonate trials, once they become available.
Appropriate selection of patients and patient monitoring by healthcare professionals can reduce the likelihood of adverse events occurring and help ensure the safe use of Reclast.
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Prolia has been studied thoroughly in clinical trials, in which the side effects occurring in a group of people taking the drug were documented and then compared to another group taking a placebo (an injection with no active ingredient).
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There is very little data for this approach, but I have had some success in later lines of treatment when I'm running out of other options.
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Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents.
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Osteonecrosis of the jaw (ONJ) has been reported predominantly in cancer patients treated with intravenous bisphosphonates, including pamidronate disodium.
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Salter (December 15, 1924 to May 10, 2010) was a world renowned Orthopedic Surgeon, professor, author, scientist and was named one of the 10 most outstanding scientists of the past 80 years by the University of Toronto Faculty of Medicine.
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Aclasta represents a new treatment option that is administered as a once-yearly infusion, unlike daily, weekly or monthly oral bisphosphonates.
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