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Because of the risk of complications, patients with ascariasis who have other concomitant helminthic infections should always undergo treatment for ascariasis first.

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It is also used as an adjunct to surgery of hydatid cysts, either preoperatively or postoperatively, to reduce the risk of recurrence due to operative spillage.

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Although combinatorial chemistry in one or more of its manifestations has now been present as a discovery source for approximately 80% of the time covered by this review, to date, we still can only find one formal de novo new chemical entity reported in the public domain, with a second possibility discovered in a similar manner, with both approved for drug use.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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