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Because of the risk of complications, patients with ascariasis who have other concomitant helminthic infections should always undergo treatment for ascariasis first.

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He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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It is also used as an adjunct to surgery of hydatid cysts, either preoperatively or postoperatively, to reduce the risk of recurrence due to operative spillage.

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However, the recent work by the Oberlies group on the production of silybins by an endophytic fungus from the leaves of the milk thistle Silybum marianum demonstrated that these metabolites were produced by the isolated fungus when supplemented by a sterilized extract from the plant, a supplementation strategy well known in the days of antibiotic discovery but generally not used today by newer investigators studying these types of systems.

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Although combinatorial chemistry in one or more of its manifestations has now been present as a discovery source for approximately 80% of the time covered by this review, to date, we still can only find one formal de novo new chemical entity reported in the public domain, with a second possibility discovered in a similar manner, with both approved for drug use.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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